Leslie Benet: search on Z-Library

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1

Clearance concepts in pharmacokinetics

Malcolm Rowland, Leslie Z. Benet, Garry G. Graham

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1973

Language:

english

File:

PDF, 653 KB

english, 1973

2

Membrane transporters in drug development

Giacomini, Kathleen M., Huang, Shiew-Mei, Tweedie, Donald J., Benet, Leslie Z., Brouwer, Kim L.R., Chu, Xiaoyan, Dahlin, Amber, Evers, Raymond, Fischer, Volker, Hillgren, Kathleen M.

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 646 KB

english, 2010

3

Two-compartment model for a drug and its metabolite: Application to acetylsalicylic acid pharmacokinetics

Malcolm Rowland, Leslie Z. Benet, Sidney Riegelman

Journal:

Journal of Pharmaceutical Sciences

Year:

1970

Language:

english

File:

PDF, 360 KB

english, 1970

4

Effect of route of administration and distribution on drug action

Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1978

Language:

english

File:

PDF, 1.64 MB

english, 1978

5

The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms

Selma Sahin, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

6

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

Sarah Shugarts, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 314 KB

english, 2009

7

The BCS, BDDCS, and Regulatory Guidances

Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas, Lawrence X. Yu

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 124 KB

english, 2011

8

Pharmacokinetics || Estimation of an Effective Half-Life

Benet, Leslie Z., Levy, Gerhard, Ferraiolo, Bobbe L.

Year:

1984

Language:

english

File:

PDF, 1.24 MB

english, 1984

9

Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Subjects and Patients with Noninsulin-Dependent Diabetes Mellitus

Sambol, Nancy C., Chiang, Janie, O'Conner, Michael, Liu, Chui Y., Lin, Emil T., Goodman, Anita M., Benet, Leslie Z., Karam, John H.

Journal:

Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 973 KB

english, 1996

10

Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations

Parasrampuria, Dolly A., Benet, Leslie Z., Sharma, Amarnath

Journal:

The AAPS Journal

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

11

Investigating the Theoretical Basis for In VitroâIn Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways

Benet, Leslie Z., Sodhi, Jasleen K.

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 800 KB

2020

12

Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis

Leslie Z. Benet, Joseph S. Turi

Journal:

Journal of Pharmaceutical Sciences

Year:

1971

Language:

english

File:

PDF, 203 KB

english, 1971

13

Interpretation of plasma concentration-time curves after oral dosing

Robert A. Ronfeld, Leslie Z. Benet

Journal:

Journal of Pharmaceutical Sciences

Year:

1977

Language:

english

File:

PDF, 386 KB

english, 1977

14

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

Gomez, Denise Y., Wacher, Vincent J., Tomlanovich, Stephen J., Hebert, Mary F., Benet, Leslie Z.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 527 KB

english, 1995

15

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

Wu, Chi-Yuan, Benet, Leslie Z., Hebert, Mary F., Gupta, Suneel K., Rowland, Malcolm, Gomez, Denise Y., Wacher, Vincent J.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1995

Language:

english

File:

PDF, 604 KB

english, 1995

16

Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation

Anita Grover, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2011

Language:

english

File:

PDF, 307 KB

english, 2011

17

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

Chi-Yuan Wu, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 388 KB

english, 2005

18

Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System

Leslie Z. Benet

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2010

Language:

english

File:

PDF, 463 KB

english, 2010

19

BDDCS Class Prediction for New Molecular Entities

Broccatelli, Fabio, Cruciani, Gabriele, Benet, Leslie Z., Oprea, Tudor I.

Journal:

Molecular Pharmaceutics

Year:

2012

Language:

english

File:

PDF, 451 KB

english, 2012

20

Effects of Drug Transporters on Volume of Distribution

Anita Grover, Leslie Z. Benet

Journal:

The AAPS Journal

Year:

2009

Language:

english

File:

PDF, 197 KB

english, 2009

21

Furosemide pharmacokinetics and pharmacodynamics in health and disease—An update

Margareta Hammarlund-Udenaes, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1989

Language:

english

File:

PDF, 2.80 MB

english, 1989

22

Pharmacokinetics/pharmacodynamics of furosemide in man: A review

Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1979

Language:

english

File:

PDF, 1.62 MB

english, 1979

23

Clearance calculations in hemodialysis: Application to blood, plasma, and dialysate measurements for ethambutol

Ching S. Lee, Thomas C. Marbury, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1980

Language:

english

File:

PDF, 726 KB

english, 1980

24

Pharmacokinetics of cefamandole using a HPLC assay

Nik S. Aziz, John G. Gambertoglio, Emil T. Lin, Henry Grausz, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1978

Language:

english

File:

PDF, 643 KB

english, 1978

25

Menopause: Pharmacodynamics and pharmacokinetics

Linda E. Gustavson, Leslie Z. Benet

Journal:

Experimental Gerontology

Year:

1994

Language:

english

File:

PDF, 442 KB

english, 1994

26

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

Joseph M. Custodio, Chi-Yuan Wu, Leslie Z. Benet

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 1.74 MB

english, 2008

27

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

Benet, Leslie Z.

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 234 KB

english, 2013

28

Report of the workshop on: in vitro and in vivo testing and correlation for oral controlled/modified release dosage forms

Skelly, Jerome P., Amidon, Gordon L., Barr, William H., Benet, Leslie Z., Carter, James E., Robinson, Joseph R., Shah, Vinod P., Yacobi, Avraham, Aiache, Jean-Marc, Albert, Kenneth S., Amidon, Gordon

Journal:

International Journal of Pharmaceutics

Year:

1990

Language:

english

File:

PDF, 1.11 MB

english, 1990

29

Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Yago, Marc R., Frymoyer, Adam R., Smelick, Gillian S., Frassetto, Lynda A., Budha, Nageshwar R., Dresser, Mark J., Ware, Joseph A., Benet, Leslie Z.

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 239 KB

english, 2013

30

The True Composition of Kidney Stones Passed During Triamterene Therapy

Sörgel, Fritz, Ettinger, Bruce, Benet, Leslie Z.

Journal:

The Journal of Urology

Year:

1985

Language:

english

File:

PDF, 122 KB

english, 1985

31

Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Phung, Nhi, Kuncze, Karen, Okochi, Hideaki, Louie, Alexander, Benet, Leslie Z., Ofokotun, Igho, Haas, David W., Currier, Judith S., Chawana, Tariro D., Sheth, Anandi N., Bacchetti, Peter, Gandhi, Moni

Journal:

Rapid Communications in Mass Spectrometry

Year:

2018

Language:

english

File:

PDF, 918 KB

english, 2018

32

Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States

Koss, Catherine A, Hosek, Sybil G, Bacchetti, Peter, Anderson, Peter L, Liu, Albert Y, Horng, Howard, Benet, Leslie Z, Kuncze, Karen, Louie, Alexander, Saberi, Parya, Wilson, Craig M, Gandhi, Monica

Journal:

Clinical Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

33

Characterization of fasiglifam-related liver toxicity in dogs

Kogame, Akifumi, Moriya, Yuu, Mori, Ikuo, Pan, Liping, Morohashi, Akio, Ebihara, Takuya, Fukui, Hideo, Tagawa, Yoshihiko, Benet, Leslie Z.

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.42 MB

english, 2019

34

How Transporters Have Changed Basic Pharmacokinetic Understanding

Benet, Leslie Z., Bowman, Christine M., Sodhi, Jasleen K.

Journal:

The AAPS Journal

Year:

2019

Language:

english

File:

PDF, 853 KB

english, 2019

35

Food, Acid Supplementation and Drug Absorption – a Complicated Gastric Mix: a Randomized Control Trial

Surofchy, Dalga D., Frassetto, Lynda A., Benet, Leslie Z.

Journal:

Pharmaceutical Research

Year:

2019

Language:

english

File:

PDF, 1.20 MB

english, 2019

36

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Year:

2020

File:

PDF, 1.27 MB

2020

37

The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions

Sodhi, Jasleen K., Benet, Leslie Z.

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 491 KB

2020

38

Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite

Takashi Mizuma, Leslie Z. Benet, Emil T. Lin

Journal:

Biopharmaceutics & Drug Disposition

Year:

1999

Language:

english

File:

PDF, 157 KB

english, 1999

39

Development of 3-nitratomethyl-proxyl (NMP): A novel, bifunctional superoxide dismutase-mimic-nitric oxide-donor

Abdullah Haj-Yehia, Taher Nassar, Chaim Lotan, Thomas Münzel, Leslie Benet, Erik E. Änggård

Journal:

Drug Development Research

Year:

2000

Language:

english

File:

PDF, 140 KB

english, 2000

40

Absorption kinetics of cyclosporine in healthy volunteers

Suneel K. Gupta, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1989

Language:

english

File:

PDF, 265 KB

english, 1989

41

Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat

David T.-W. Lau, Mark Gumbleton, Christoph Labisch, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1991

Language:

english

File:

PDF, 393 KB

english, 1991

42

Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations

Margareta Hammarlund-udenaes, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1991

Language:

english

File:

PDF, 571 KB

english, 1991

43

Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration

Chao Han, Paul Jung, Steven W. Sanders, Emil T. Lin, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1994

Language:

english

File:

PDF, 249 KB

english, 1994

44

Time course of cyclosporine and its metabolites in blood, liver and spleen of naive lewis rats: Comparison with preliminary data obtained in transplanted animals

Vincent J. Wacher, Tao Liu, John P. Roberts, Nancy L. Ascher, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1995

Language:

english

File:

PDF, 521 KB

english, 1995

45

Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing

Dale K. Yu, Dennis H. Giesing, Roger L. Williams, Leslie Z. Benet, Emil T. Lin

Journal:

Biopharmaceutics & Drug Disposition

Year:

1988

Language:

english

File:

PDF, 401 KB

english, 1988

46

Novel percutaneous adventitial drug delivery system for regional vascular treatment

Fumiaki Ikeno, Jennifer Lyons, Hideaki Kaneda, Muhammad Baluom, Leslie Z. Benet, Mehrdad Rezaee

Journal:

Catheterization and Cardiovascular Interventions

Year:

2004

Language:

english

File:

PDF, 597 KB

english, 2004

47

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers

Sascha Mayer, Ernst Mutschler, Dr. Hildegard Spahn-Langguth, Leslie Z. Benet

Journal:

Year:

1993

Language:

english

File:

PDF, 585 KB

english, 1993

48

Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus

K. Olaf Boernsen, Wolfgang Egge-Jacobsen, Bruno Inverardi, Tobin Strom, Frank Streit, Hans-Martin Schiebel, Leslie Z. Benet, Uwe Christians

Journal:

Journal of Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 198 KB

english, 2007

49

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells

Shawn D. Flanagan, Lpori H. Takahashi, Xiaoli Liu, Leslie Z. Benet

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

50

Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells

Wendy S. Putnam, Srinivasan Ramanathan, Lin Pan, Lori H. Takahashi, Leslie Z. Benet

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002